Comparative analysis of the Pharmacological Evaluation of plant Extract Assessing on Rheumatoid arthritis in Experimental rats

Abstract

Objective: The goal of the present study was to clarifying the effects of medicinal herbs on the CFA-induced paw edema model.

Materials and Methods: Materials and Methods: Male Wistar rats  divided in to 7 groups: Group1-Control, Group 2-Negative control, Group 3- Sulfasalazine 80 mg/kg, Group-4 Lagerstroemia speciosa 500 mg/kg Group 5-Nyctanthes arbortristis 400 mg/kg, Group-6 Vitex negundo 450 mg/kg, Group-7  Nyctanthes arbortristis 100mg/kg, Vitex negundo 100mg/kg, Lagerstroemia speciosa 100mg/kg (Therapeutic).  Evaluation was conducted on the 28th day using a range of behavioral tests, including body weight, erythrocyte sedimentation rate, arthritic scale, hind paw volume and edema, and histological data. One Way ANOVA was used to analyze the data, and Dunnett's test (p<0.05) was used to evaluate statistical significance.

Results:  The arthritis scale showed a substantial (p<0.05) decrease in body weight in the arthritis control group., erythrocyte sedimentation rate, histological markers, and hind paw volume and edema in comparison to the preventative therapy and therapeutic treatment groups. The use of medicinal herbs as a preventive measure resulted in substantial (p<0.05) improvements in body weight, arthritis score, erythrocyte sedimentation rate, antioxidant and hind paw volume and edema. Furthermore, the anti-arthritic effects were significantly (p < 0.05) increased when Nyctanthes arbortristis, Vitex negundo, and Lagerstroemia speciosa were given simultaneously at dosages of 100 milligrams per kilogram and 100 milligrams per kilogram, respectively.