A Novel Approach: Formulation and Evaluation of Herbal Emulgel Loaded with Extract of Cedrus deodara for its In-Vitro Anti-Inflammatory Activity

Abstract

The aim of present study is to development of novel formulation present unique challenge.  In the current study researchers are greatly interested in discovering the potential of natural bioactive components. Remedial effects are produced by different plant extracts. Cedrus deodara is found in North India, Pakistan, Afghanistan, Tibet and Nepal. It contains deodarin, cedodarin, taxifolin, myrcene, iso-pimpillin, α-pinene, β-pinene, cedrin, deodarone, sesquiterpene, cedrinoside, dihydromyricetin, matairesinol, atlantone. It is used in treatment of inflammation, ulcer, pain, hyperglycemia, infection, insomnia, skin disorder, blood disorder, apoptosis, fever. Recently in-vivo and in-vitro studies have indicated its anti-inflammatory and analgesic property. The objectives of proposed research work are to formulate and evaluate the herbal emulgel loaded with extract of Cedrus deodara and evaluate for its In-Vitro Anti-Inflammatory Activity. Cedrus deodara heartwood was extracted using hydro-alcoholic solvent. Phytochemical evaluation of extract was done. Six batches of herbal emulgel were formulated. The prepared herbal emulgel was evaluated for pH, spreadability, viscosity, consistency, appearance, color, washability and appearance. In-vitro anti-inflammatory activity of extract and formulation were done using HRBC Membrane stabilization assay and protein denaturation assay. The proposed research work concludes that the newly formulated herbal emulgel loaded with extract of Cedrus deodara can be used in future for anti-inflammatory effect.