A Comprehensive Review On Nanoemulsions Used In Intranasal Drug Delivery System

Abstract

The goal of this review is to highlight the passage of the blood-brain barrier by the olfactory trigeminal nerve pathway, which show drugs are transported from the brain to the nose. The administration of drugs through the nose to the brain has garnered significant interest because to its convenience, safety, and non-invasive nature. There are many advantages like quick start of action, simplicity of administration, noninvasive, by crossing the blood-brain barrier, enhanced bioavailability, self-administration, lower dosage/fewer adverse effects, and quick absorption of the medication through a highly vascularized mucosa Liquid dosage forms, such as nasal sprays, nanoparticles, microemulsions for the nose, and semisolid dosage forms, are among the several ways that medications are administered to the brain and nervous system following intranasal delivery. When designing a delivery system for the nose, materials such as gels, ointments, and liquid systems with polymers that gel at certain pH changes are typically used and also while originally tailored for pulmonary drug delivery and its associated uses, there's a growing trend towards employing solid dosage forms for intranasal drug administration. For instance, nasal powders have better medication stability and no preservative in their composition. Nano emulsions are promising formulations for intranasal medication delivery that can reach the brain directly. In order to avoid issues like sluggish beginning of action, limited bioavailability and enzymatic degradation, as well as poor solubility in water they can be utilised as a potential substitute for oral delivery .For the treatment of neurological illnesses, nasal Nano emulsions seem to be a safe, effective, and non-invasive method of delivering medicine.